Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet

In order to investigate how IKr and IKs inhibitions affect waveforms of the field potential in the human iPS cell-derived cardiomyocytes sheet, we analyzed the effects of E-4031 and chromanol 293B on the maximum upslope and peak amplitude of its second wave (n = 7 for each drug). E-4031 in 10–100 nM...

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Bibliographic Details
Main Authors: Junko Matsuo, Yuji Nakamura, Hiroko Izumi-Nakaseko, Kentaro Ando, Yuko Sekino, Atsushi Sugiyama
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Pharmacological Sciences
Subjects:
IKr
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000924