Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex (PLC) components is expected to ensure the cell surface expression of stable peptide-...

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Bibliographic Details
Main Authors: Brogan Yarzabek, Anita J Zaitouna, Eli Olson, Gayathri N Silva, Jie Geng, Aviva Geretz, Rasmi Thomas, Sujatha Krishnakumar, Daniel S Ramon, Malini Raghavan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
HLA-B
MHC class I
half-life
expression
peptidome
transporter associated with antigen processing
Online Access:https://elifesciences.org/articles/34961

Internet

https://elifesciences.org/articles/34961

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