Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynony...

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Main Authors: Michael Hawkes, Andrea L. Conroy, Robert O. Opoka, Sophie Namasopo, Kathleen Zhong, W. Conrad Liles, Chandy C. John, Kevin C. Kain
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2015-07-01
Series:Emerging Infectious Diseases
Subjects:
malaria
artesunate
resistance
child
single nucleotide polymorphism
kelch 13 propeller domain
Online Access:https://wwwnc.cdc.gov/eid/article/21/7/15-0213_article
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spelling doaj-5d76e76b86fd4222bbd384742a214c642020-11-25T02:35:12ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-07-012171237123910.3201/eid2107.150213Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013Michael HawkesAndrea L. ConroyRobert O. OpokaSophie NamasopoKathleen ZhongW. Conrad LilesChandy C. JohnKevin C. KainPlasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.https://wwwnc.cdc.gov/eid/article/21/7/15-0213_articlemalariaartesunateresistancechildsingle nucleotide polymorphismkelch 13 propeller domain
collection DOAJ
language English
format Article
sources DOAJ
author Michael Hawkes
Andrea L. Conroy
Robert O. Opoka
Sophie Namasopo
Kathleen Zhong
W. Conrad Liles
Chandy C. John
Kevin C. Kain
spellingShingle Michael Hawkes
Andrea L. Conroy
Robert O. Opoka
Sophie Namasopo
Kathleen Zhong
W. Conrad Liles
Chandy C. John
Kevin C. Kain
Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
Emerging Infectious Diseases
malaria
artesunate
resistance
child
single nucleotide polymorphism
kelch 13 propeller domain
author_facet Michael Hawkes
Andrea L. Conroy
Robert O. Opoka
Sophie Namasopo
Kathleen Zhong
W. Conrad Liles
Chandy C. John
Kevin C. Kain
author_sort Michael Hawkes
title Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_short Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_full Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_fullStr Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_full_unstemmed Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_sort slow clearance of plasmodium falciparum in severe pediatric malaria, uganda, 2011–2013
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2015-07-01
description Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
topic malaria
artesunate
resistance
child
single nucleotide polymorphism
kelch 13 propeller domain
url https://wwwnc.cdc.gov/eid/article/21/7/15-0213_article
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