Potential Molecular Mechanisms for Improved Prognosis and Outcome with Neoadjuvant Chemotherapy Prior to Laparoscopical Radical Hysterectomy for Patients with Cervical Cancer

Potential Molecular Mechanisms for Improved Prognosis and Outcome with Neoadjuvant Chemotherapy Prior to Laparoscopical Radical Hysterectomy for Patients with Cervical Cancer

Background: The p53:miR-34a:E2F positive feed-forward loop and the p53:miR-605:Mdm2 positive feed-back loop have been identified to be crucial oncogenesis/tumor suppressor-regulating signaling pathways. In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a bette...

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Bibliographic Details
Main Authors: Hongzan Sun, Jun Xin, Zaiming Lu, Ning Wang, Ning Liu, Qiyong Guo
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Neoadjuvant chemotherapy (NAC)
ERK1/2
TAB1
Cervical cancer
miRNAs
miR-34a
miR-605
p53
E2F
Mdm2
Cisplatin
Paclitaxel
Carboplatin
Online Access:http://www.karger.com/Article/FullText/356590

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