Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models

Progressive accumulation of the pre-synaptic protein α-synuclein (α-syn) has been strongly associated with the pathogenesis of neurodegenerative disorders of the aging population such as Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy....

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Bibliographic Details
Main Authors: Michiyo Iba, Changyoun Kim, Jazmin Florio, Michael Mante, Anthony Adame, Edward Rockenstein, Somin Kwon, Robert Rissman, Eliezer Masliah
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
MAPK
p38gamma
dementia with Lewy bodies
synucleinopathies
synaptic pathology
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00286/full

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