Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis

Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by gradual degeneration and elimination of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord. Some familial forms of ALS are caused by genetic mutations in superoxide dismutase 1 (SOD1) but the...

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Bibliographic Details
Main Authors: Byung Woo Kim, Jiwon Ryu, Ye Eun Jeong, Juhyun Kim, Lee J. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ALS
SOD1
G93A
CRISPR/Cas9
iPSC
motor neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.604171/full

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https://www.frontiersin.org/articles/10.3389/fncel.2020.604171/full

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