Hydrotalcite Intercalated siRNA: Computational Characterization of the Interlayer Environment

Hydrotalcite Intercalated siRNA: Computational Characterization of the Interlayer Environment

Using molecular dynamics (MD) simulations, we explore the structural and dynamical properties of siRNA within the intercalated environment of a <em>Mg</em>:<em>Al</em> 2:1 Layered Double Hydroxide (LDH) nanoparticle. An <em>ab ini...

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Bibliographic Details
Main Authors: Sean C. Smith, Zhiping Xu, Vinuthaa Murthy, Hong Zhang, Yunyi Wong, Defang Ouyang
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Pharmaceutics
Subjects:
layered double hydroxide
molecular dynamics simulations
siRNA delivery
gene therapy
Online Access:http://www.mdpi.com/1999-4923/4/2/296

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http://www.mdpi.com/1999-4923/4/2/296

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