A highly focused antigen receptor repertoire characterizes γδ T cells that are poised to make IL-17 rapidly in naive animals

A highly focused antigen receptor repertoire characterizes γδ T cells that are poised to make IL-17 rapidly in naive animals

Interleukin (IL)-17 plays a key role in immunity. In acute infections, a rapid IL-17 response must be induced without prior antigen exposure, and γδ T cells are the major initial IL-17 producers. In fact, some γδ T cells make IL-17 within hours after an immune challenge. These cells appear to acquir...

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Bibliographic Details
Main Authors: Yu-Ling eWei, Arnold eHan, Jacob eGlanville, Fengqin eFang, Luis Alejandro Zuniga, Jacob eLee, Daniel eCua, Yueh-Hsiu eChien
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Immunology
Subjects:
TCR repertoire
γδ T cells
IL23R+ γδ T cells
IL-17+ γδ T cells
high throughput TCR sequencing
IL-1R+ γδT cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00118/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00118/full

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