Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya

Abstract Background There are concerns that resistance to artemisinin-based combination therapy might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with chloroquine and sulfadoxine–pyrimethamine. Single nucleotide polymorphisms (SNPs) in critical alleles of pfmdr1 gene have...

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Bibliographic Details
Main Authors: Peninah Muiruri, Denis W. Juma, Luicer A. Ingasia, Lorna J. Chebon, Benjamin Opot, Bidii S. Ngalah, Jelagat Cheruiyot, Ben Andagalu, Hoseah M. Akala, Venny C. S. Nyambati, Joseph K. Ng’ang’a, Edwin Kamau
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Malaria Journal
Subjects:
Soft selective sweeps
Genetic lineages
Artemisinin resistance
Online Access:http://link.springer.com/article/10.1186/s12936-018-2534-8

Internet

http://link.springer.com/article/10.1186/s12936-018-2534-8

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