Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells.

Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells.

BACKGROUND: Cyclooxygenase-2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostanoids, and its activation is associated with carcinogenesis as well as inflammation. The antitumor effect of selective COX-2 inhibitors has been noted in various malignancies. Malignant peripheral ner...

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Bibliographic Details
Main Authors: Michiyuki Hakozaki, Takahiro Tajino, Shinichi Konno, Shinichi Kikuchi, Hitoshi Yamada, Michiro Yanagisawa, Jun Nishida, Hiroyuki Nagasawa, Takashi Tsuchiya, Akira Ogose, Masafumi Abe, Hiroshi Hojo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3916395?pdf=render

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http://europepmc.org/articles/PMC3916395?pdf=render

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