The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling

The adipokine leptin modulates adventitial pericyte functions by autocrine and paracrine signalling

Abstract Transplantation of adventitial pericytes (APCs) improves recovery from tissue ischemia in preclinical animal models by still unknown mechanisms. This study investigates the role of the adipokine leptin (LEP) in the regulation of human APC biological functions. Transcriptomic analysis of APC...

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Bibliographic Details
Main Authors: Federica Riu, Sadie C. Slater, Eva Jover Garcia, Iker Rodriguez-Arabaolaza, Valeria Alvino, Elisa Avolio, Giuseppe Mangialardi, Andrea Cordaro, Simon Satchell, Carlo Zebele, Andrea Caporali, Gianni Angelini, Paolo Madeddu
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05868-y

Internet

https://doi.org/10.1038/s41598-017-05868-y

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