Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology

Gene Expression and Protein Abundance of Hepatic Drug Metabolizing Enzymes in Liver Pathology

Hepatic drug metabolizing enzymes (DMEs) markedly affect drug pharmacokinetics. Because liver diseases may alter enzymatic function and in turn drug handling and clinical efficacy, we investigated DMEs expression in dependence on liver pathology and liver failure state. In 5 liver pathologies (hepat...

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Bibliographic Details
Main Authors: Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Łukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
hepatic pathology
liver
drug metabolizing enzymes
Online Access:https://www.mdpi.com/1999-4923/13/9/1334

Internet

https://www.mdpi.com/1999-4923/13/9/1334

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