Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.

Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension.

OBJECTIVE:Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of the class I HDAC selective inhibitors, MS-275 and RGFP966, in angiotensin (Ang) II-induced hypertensive mice. METHODS AND RESULTS:...

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Bibliographic Details
Main Authors: Yuhee Ryu, Hae Jin Kee, Simei Sun, Young Mi Seok, Sin Young Choi, Gwi Ran Kim, Seung-Jung Kee, Marc Pflieger, Thomas Kurz, Hyung-Seok Kim, Myung Ho Jeong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213186

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https://doi.org/10.1371/journal.pone.0213186

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