The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-γ-dependent host protection in vivo. However, these protective effects occur independently of autophagosome formation. Thus, the in vivo role of classic autophagy in protection conferred by adapti...

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Bibliographic Details
Main Authors: Jose-Andres C Portillo, Genevieve Okenka, Erin Reed, Angela Subauste, Jennifer Van Grol, Katrin Gentil, Masaaki Komatsu, Keiji Tanaka, Gary Landreth, Beth Levine, Carlos S Subauste
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3013095?pdf=render

Internet

http://europepmc.org/articles/PMC3013095?pdf=render

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