Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells

Abstract Background Acquirement of resistance is always associated with a highly aggressive phenotype of tumor cells. Recent studies have revealed that Annexin A2 (Anxa2) is a key protein that links drug resistance and cancer metastasis. A high level of Anxa2 in cancer tissues is correlated to a hig...

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Bibliographic Details
Main Authors: Yanling Fan, Weiyao Si, Wei Ji, Zhiyong Wang, Zicong Gao, Ran Tian, Weijie Song, He Zhang, Ruifang Niu, Fei Zhang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Breast Cancer Research
Subjects:
Rack1
Anxa2
Src
Drug resistance
Invasion
Metastasis
Online Access:http://link.springer.com/article/10.1186/s13058-019-1147-7

Internet

http://link.springer.com/article/10.1186/s13058-019-1147-7

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