Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

High-grade serous carcinomas (HGSCs) are associated with precursor lesions (STICs) in the fallopian epithelium in only half of the cases. Here the authors report the molecular analysis of HGSCs with and without associated STICs and show similar profiles supporting a common origin for all HGSCs.

Bibliographic Details
Main Authors: Jennifer Ducie, Fanny Dao, Michael Considine, Narciso Olvera, Patricia A. Shaw, Robert J. Kurman, Ie-Ming Shih, Robert A. Soslow, Leslie Cope, Douglas A. Levine
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01217-9