Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in

Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in

There is a strong unmet need for translational progress towards Alzheimer's disease (AD) modifying therapy. Unfortunately, preclinical modeling of the disease has been disappointing, relying primarily on transgenic mouse overexpression of rare dominant mutations. Clinical manifestation of AD sy...

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Bibliographic Details
Main Authors: Marius Chiasseu, Arman Fesharaki-Zadeh, Takashi Saito, Takaomi C. Saido, Stephen M. Strittmatter
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Repeated mild traumatic brain injury
Amyloid-beta
Tau protein
Neuroinflammation
Cognitive decline
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030334X

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http://www.sciencedirect.com/science/article/pii/S096999612030334X

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