Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing Streptomyces. Streptomyces species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has greater functional significance. We found tha...

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Bibliographic Details
Main Authors: Emma J Gehrke, Xiafei Zhang, Sheila M Pimentel-Elardo, Andrew R Johnson, Christiaan A Rees, Stephanie E Jones, Hindra, Sebastian S Gehrke, Sonya Turvey, Suzanne Boursalie, Jane E Hill, Erin E Carlson, Justin R Nodwell, Marie A Elliot
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
Streptomyces
nucleoid-associated protein
specialized metabolism
DNA-binding protein
repressor
antibiotics
Online Access:https://elifesciences.org/articles/47691

Internet

https://elifesciences.org/articles/47691

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