Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that aquaporin-4 (AQP4) water channels facilitate c...

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Bibliographic Details
Main Authors: Alex J Smith, Xiaoming Yao, James A Dix, Byung-Ju Jin, Alan S Verkman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
extracellular space
aquaporin 4
CSF
glymphatic hypothesis
convection
diffusion
Online Access:https://elifesciences.org/articles/27679

Internet

https://elifesciences.org/articles/27679

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