Insulin and glucagon regulate pancreatic α-cell proliferation.

Insulin and glucagon regulate pancreatic α-cell proliferation.

Type 2 diabetes mellitus (T2DM) results from insulin resistance and β-cell dysfunction, in the setting of hyperglucagonemia. Glucagon is a 29 amino acid peptide hormone, which is secreted from pancreatic α cells: excessively high circulating levels of glucagon lead to excessive hepatic glucose outpu...

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Bibliographic Details
Main Authors: Zhuo Liu, Wook Kim, Zhike Chen, Yu-Kyong Shin, Olga D Carlson, Jennifer L Fiori, Li Xin, Joshua K Napora, Ryan Short, Juliana O Odetunde, Qizong Lao, Josephine M Egan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3026810?pdf=render

Internet

http://europepmc.org/articles/PMC3026810?pdf=render

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