Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth

Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth

RIDR-PI-103 is a novel reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103). Under high ROS, PI-103 is released in a controlled manner to inhibit PI3K. The efficacy and bioavailability of RIDR-PI-103 in breast cancer remains...

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Bibliographic Details
Main Authors: Rosalin Mishra, Long Yuan, Hima Patel, Aniruddha S. Karve, Haizhou Zhu, Aaron White, Samar Alanazi, Pankaj Desai, Edward J. Merino, Joan T. Garrett
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
reactive oxygen species
RIDR-PI-103
doxorubicin
Online Access:https://www.mdpi.com/1422-0067/22/4/2088

Internet

https://www.mdpi.com/1422-0067/22/4/2088

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