Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon.

Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon.

Type 2 diabetes is characterized by peripheral insulin resistance and pancreatic beta cell dysfunction. Elevated free fatty acids (FFAs) may impair beta cell function and mass (lipotoxicity). Altered calcium homeostasis may be involved in defective insulin release. The endoplasmic reticulum (ER) is...

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Bibliographic Details
Main Authors: R Cassel, S Ducreux, M R Alam, F Dingreville, C Berlé, K Burda-Jacob, M A Chauvin, K Chikh, L Païta, R Al-Mawla, C Crola Da Silva, J Rieusset, C Thivolet, F Van Coppenolle, A M Madec
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4749224?pdf=render

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http://europepmc.org/articles/PMC4749224?pdf=render

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