SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

Abstract Background Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation a...

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Bibliographic Details
Main Authors: Özgen Deniz, Lorenzo de la Rica, Kevin C. L. Cheng, Dominik Spensberger, Miguel R. Branco
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genome Biology
Subjects:
Embryonic stem cells
Retrotransposons
Intracisternal A particles (IAPs)
SETDB1
Ten-eleven translocation enzymes
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s13059-017-1376-y

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http://link.springer.com/article/10.1186/s13059-017-1376-y

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