Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

Abstract Background Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal zone and the cerebral lateral ventricles. The consequent blood clot has been identified as the causative factor of seco...

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Bibliographic Details
Main Authors: Jie Xiao, Tao Cai, Yuanjian Fang, Rui Liu, Jerry J. Flores, Wenna Wang, Ling Gao, Yu Liu, Qin Lu, Lihui Tang, John H. Zhang, Hongwei Lu, Jiping Tang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
GPR40
Germinal matrix hemorrhage
Microglia
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-021-02209-9

Internet

https://doi.org/10.1186/s12974-021-02209-9

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