Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice

Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice

The present study was conducted to characterize microRNA-200c (miR-200c) and its regulators in adipogenic differentiation, obesity, and periodontitis in obese subjects (PiOSs), and to determine the therapeutic efficacy of plasmid DNA encoding miR-200c as a treatment for PiOSs. We report that highly...

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Bibliographic Details
Main Authors: Tadkamol Krongbaramee, Min Zhu, Qingwen Qian, Zeyuan Zhang, Steven Eliason, Yi Shu, Fang Qian, Adil Akkouch, Dan Su, Brad A. Amendt, Ling Yang, Liu Hong
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
periodontitis
obesity
microRNA-200c
gene therapy
mouse
IL-6
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000305

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http://www.sciencedirect.com/science/article/pii/S2162253121000305

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