Antinociceptive Effects of Sinomenine Combined With Ligustrazine or Paracetamol in Animal Models of Incisional and Inflammatory Pain

Antinociceptive Effects of Sinomenine Combined With Ligustrazine or Paracetamol in Animal Models of Incisional and Inflammatory Pain

The management of postoperative and inflammatory pain has been a pressing challenge in clinical settings. Sinomenine (SN) is a morphinan derived alkaloid with remarkable analgesic properties in various kinds of pain models. The aim of the current study is to investigate if SN can enhance the effect...

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Bibliographic Details
Main Authors: Tianle Gao, Tao Li, Wei Jiang, Weiming Fan, Xiao-Jun Xu, Xiaoliang Zhao, Zhenming Yin, Huihui Guo, Lulu Wang, Jun Gao, Yanxing Han, Jian-Dong Jiang, Danqiao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Physiology
Subjects:
neuroimmune interaction
post-operative pain
carrageenan-induced inflammation
drug combinations
pharmacokinetics
microdialysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.523769/full

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https://www.frontiersin.org/articles/10.3389/fphys.2020.523769/full

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