Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets

Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets

Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly function by cutting ubiquitin chains of the substrates. The Machad...

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Bibliographic Details
Main Authors: Chenming Zeng, Chenxi Zhao, Fujing Ge, Yuekang Li, Ji Cao, Meidan Ying, Jinjian Lu, Qiaojun He, Bo Yang, Xiaoyang Dai, Hong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
deubiquitinase
Machado-Joseph domain-containing proteases
MJD disease
cellular functions
cancer therapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01311/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01311/full

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