Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic PancreatitisSummary

Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic PancreatitisSummary

Background & Aims: Maintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways plays a central role in the development and progression of pancreatitis....

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Bibliographic Details
Main Authors: Michelle M. Cooley, Diana D.H. Thomas, Kali Deans, Yajing Peng, Aurelia Lugea, Stephen J. Pandol, Luigi Puglielli, Guy E. Groblewski
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
AT-1
ER Stress
Unfolded Protein Response
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301715

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X20301715

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