Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

T cell receptor (TCR) engagement opens Ca2+ release-activated Ca2+ (CRAC) channels and triggers formation of an immune synapse between T cells and antigen-presenting cells. At the synapse, actin reorganizes into a concentric lamellipod and lamella with retrograde actin flow that helps regulate the i...

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Bibliographic Details
Main Authors: Catherine A Hartzell, Katarzyna I Jankowska, Janis K Burkhardt, Richard S Lewis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
immunological synapse
endoplasmic reticulum
T lymphocyte
actin dynamics
calcium release-activated calcium (CRAC) channels
calcium
Online Access:https://elifesciences.org/articles/14850

Internet

https://elifesciences.org/articles/14850

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