mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation

mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation

PGE2 is a lipid mediator of the initiation and resolution phases of inflammation, as well as a regulator of immune system responses to inflammatory events. PGE2 is produced and sensed by T cells, and autocrine or paracrine PGE2 can affect T cell phenotype and function. In this study, we use a T cell...

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Bibliographic Details
Main Authors: Damian Maseda, Amrita Banerjee, Elizabeth M. Johnson, Mary Kay Washington, Hyeyon Kim, Ken S. Lau, Leslie J. Crofford
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
IBD–inflammatory bowel diseases
T cell
PGE2
colitis
Th17 & Tregs cells
inflammation immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02954/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02954/full

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