KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication. The zinc finger antiviral protein (ZAP) binds regions of viral RNA containing CpGs and targets them for degradation. ZAP does not have enzymatic a...

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Bibliographic Details
Main Authors: Mattia Ficarelli, Harry Wilson, Rui Pedro Galão, Michela Mazzon, Irati Antzin-Anduetza, Mark Marsh, Stuart JD Neil, Chad M Swanson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
HIV
CpG dinucleotide
ZAP
TRIM25
KHNYN
innate immunity
Online Access:https://elifesciences.org/articles/46767

Internet

https://elifesciences.org/articles/46767

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