Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones

Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones

ABSTRACT N-acylhydrazone is an interesting privileged structure that has been used in the molecular design of a myriad of bioactive compounds. In order to identify new antinociceptive drug candidates, we described herein the design, synthesis, X-ray diffraction study and the pharmacological evaluati...

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Bibliographic Details
Main Authors: SONJA HERRMANN, TABEA SCHÜBEL, FANNY N. COSTA, MARIA LETÍCIA C. BARBOSA, FABIO F. FERREIRA, THAYS L.M.F. DIAS, MORGANA V. ARAÚJO, MAGNA S. ALEXANDRE-MOREIRA, LÍDIA M. LIMA, STEFAN LAUFER, ELIEZER J. BARREIRO
Format: Article
Language:English
Published: Academia Brasileira de Ciências
Series:Anais da Academia Brasileira de Ciências
Subjects:
N-acylhydrazone
privileged structure
antinociceptive
p38MAPK
X-ray
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301073&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301073&lng=en&tlng=en

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