Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction

The molecular mechanisms of chronic pain are poorly understood and effective mechanism-based treatments are lacking. Here, we report that mice lacking adenosine deaminase (ADA), an enzyme necessary for the breakdown of adenosine, displayed unexpected chronic mechanical and thermal hypersensitivity d...

Full description

Bibliographic Details
Main Authors: Xia Hu, Morayo G. Adebiyi, Jialie Luo, Kaiqi Sun, Thanh-Thuy T. Le, Yujin Zhang, Hongyu Wu, Shushan Zhao, Harry Karmouty-Quintana, Hong Liu, Aji Huang, Yuan Edward Wen, Oleg L. Zaika, Mykola Mamenko, Oleh M. Pochynyuk, Rodney E. Kellems, Holger K. Eltzschig, Michael R. Blackburn, Edgar T. Walters, Dong Huang, Hongzhen Hu, Yang Xia
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306933

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716306933

Similar Items