Solubility and dissolution studies of tibolone polymorphs

Solubility and dissolution studies of tibolone polymorphs

ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and ch...

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Bibliographic Details
Main Authors: Rudy Bonfilio, Marília Cristina Oliveira Souza, Jockastta Silva Leal, Olímpia Maria Martins Santos Viana, Antônio Carlos Doriguetto, Magali Benjamin de Araújo
Format: Article
Language:English
Published: Universidade de São Paulo 2018-03-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Tibolone/polymorphs
Powder X-ray diffraction/methods
Infrared spectroscopy/methods
Solubility/drug effects
Dissolution/analysis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400607&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400607&lng=en&tlng=en

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