A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.

A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.

Natural immunity or resistance to pathogens most often relies on the genetic make-up of the host. In a LEW rat model of refractoriness to toxoplasmosis, we previously identified on chromosome 10 the Toxo1 locus that directs toxoplasmosis outcome and controls parasite spreading by a macrophage-depend...

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Bibliographic Details
Main Authors: Pierre Cavailles, Pierre Flori, Olivier Papapietro, Cordelia Bisanz, Dominique Lagrange, Ludovic Pilloux, Céline Massera, Sara Cristinelli, Delphine Jublot, Olivier Bastien, Corinne Loeuillet, Delphine Aldebert, Bastien Touquet, Gilbert J Fournié, Marie France Cesbron-Delauw
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3974857?pdf=render

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http://europepmc.org/articles/PMC3974857?pdf=render

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