Evolutionary Trajectories and Genomic Divergence in Localized Breast Cancers after Ipsilateral Breast Tumor Recurrence

Evolutionary Trajectories and Genomic Divergence in Localized Breast Cancers after Ipsilateral Breast Tumor Recurrence

The evolutionary trajectories that drive clinical and therapeutic consequences in localized breast cancers (BCs) with ipsilateral breast tumor relapse (IBTR) remain largely unknown. Analyses of longitudinal paired whole-exome sequencing data from 10 localized BC patients with IBTR reveal that, compa...

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Bibliographic Details
Main Authors: Chia-Hsin Wu, Hsien-Tang Yeh, Chia-Shan Hsieh, Chi-Cheng Huang, Amrita Chattopadhyay, Yuan-Chiang Chung, Shih-Hsin Tu, Yung-Hua Li, Tzu-Pin Lu, Liang-Chuan Lai, Ming-Feng Hou, King-Jen Chang, Mong-Hsun Tsai, Eric Y. Chuang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
ipsilateral breast tumor relapse
whole-exome sequencing
clonal architecture
alteration
actionability
Online Access:https://www.mdpi.com/2072-6694/13/8/1821

Internet

https://www.mdpi.com/2072-6694/13/8/1821

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