Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

Summary: Despite a growing appreciation of γδ T cell contributions to numerous immune responses, the mechanisms that underpin their thymic development remain poorly understood. Here, using precursor/product relationships, we identify thymic stages in two distinct developmental pathways that generate...

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Bibliographic Details
Main Authors: Nital Sumaria, Capucine L. Grandjean, Bruno Silva-Santos, Daniel J. Pennington
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307283