Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mic...

Full description

Bibliographic Details
Main Authors: Doo Ri Park, Jihee Kim, Gyeong Min Kim, Haeseung Lee, Minhee Kim, Donghyun Hwang, Hana Lee, Han-Sung Kim, Wankyu Kim, Min Chan Park, Hyunbo Shim, Soo Young Lee
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18208-y

Internet

https://doi.org/10.1038/s41467-020-18208-y

Similar Items