Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size

Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size

Macrolide antibiotic binding to the ribosome inhibits catalysis of peptide bond formation between specific donor and acceptor substrates. Why particular reactions are problematic for the macrolide-bound ribosome remains unclear. Using comprehensive mutational analysis and biochemical experiments wit...

Full description

Bibliographic Details
Main Authors: Shanmugapriya Sothiselvam, Sandro Neuner, Lukas Rigger, Dorota Klepacki, Ronald Micura, Nora Vázquez-Laslop, Alexander S. Mankin
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309044

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716309044

Similar Items