Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?

Abstract Introduction Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs asses...

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Bibliographic Details
Main Authors: Rafael Dal-Ré, Perrine Janiaud, John P. A. Ioannidis
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Medicine
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12916-018-1038-2