Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colitis chronicit...

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Main Authors: Tiago Rodrigues-Sousa, Ana Filipa Ladeirinha, Ana Raquel Santiago, Helena Carvalheiro, Bruno Raposo, Ana Alarcão, António Cabrita, Rikard Holmdahl, Lina Carvalho, M Margarida Souto-Carneiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4038546?pdf=render

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http://europepmc.org/articles/PMC4038546?pdf=render

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