PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

Abstract Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescence, which can inhibit oncogene-induced tumor initiation. Functions and mechanisms of action of PLA2R1...

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Bibliographic Details
Main Authors: Anda Huna, Audrey Griveau, David Vindrieux, Sara Jaber, Jean-Michel Flaman, Delphine Goehrig, Lamia Azzi, Jean-Jacques Médard, Sophia Djebali, Hector Hernandez-Vargas, Robert Dante, Léa Payen, Jacqueline Marvel, Philippe Bertolino, Sébastien Aubert, Pierre Dubus, David Bernard
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03468-3

Internet

https://doi.org/10.1038/s41419-021-03468-3

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