Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability

Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability

Oligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophn1 affects neuronal development is only partly understood. Here we have exploited adult hippocampal neurogenesis to dissect the steps of neuronal differ...

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Bibliographic Details
Main Authors: Manuela Allegra, Cristina Spalletti, Beatrice Vignoli, Stefano Azzimondi, Irene Busti, Pierre Billuart, Marco Canossa, Matteo Caleo
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
Rho GTPase
Axon extension
Dendritic spines
Fasudil
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300037

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http://www.sciencedirect.com/science/article/pii/S0969996117300037

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