The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients

The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients

Epidermal keratinocytes represent a rich source of C-C motif chemokine 20 (CCL20) and recruit CCR6<sup>+</sup> interleukin (IL)-17A&#8722;producing T cells that are known to be pathogenic for psoriasis. A previous study revealed that scratch injury on keratinocytes upregulates CCL20...

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Bibliographic Details
Main Authors: Kazuhisa Furue, Takamichi Ito, Yuka Tanaka, Akiko Hashimoto-Hachiya, Masaki Takemura, Maho Murata, Makiko Kido-Nakahara, Gaku Tsuji, Takeshi Nakahara, Masutaka Furue
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
ccl20
il-17a
psoriasis
scratch injury
epidermal growth factor receptor
koebner phenomenon
erk
jnk
p38 mapk
keratinocyte
Online Access:https://www.mdpi.com/1422-0067/21/2/434

Internet

https://www.mdpi.com/1422-0067/21/2/434

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