Chidamide Combined With Doxorubicin Induced p53-Driven Cell Cycle Arrest and Cell Apoptosis Reverse Multidrug Resistance of Breast Cancer

Chidamide Combined With Doxorubicin Induced p53-Driven Cell Cycle Arrest and Cell Apoptosis Reverse Multidrug Resistance of Breast Cancer

The multidrug-resistant (MDR) phenotype is usually accompanied by an abnormal expression of histone deacetylase (HDAC). Given that HDAC is vital in chromatin remodeling and epigenetics, inhibiting the role of HDAC has become an important approach for tumor treatment. However, the effect of HDAC inhi...

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Bibliographic Details
Main Authors: Lixia Cao, Shaorong Zhao, Qianxi Yang, Zhendong Shi, Jingjing Liu, Teng Pan, Dongdong Zhou, Jin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
breast cancer
histone deacetylase
chidamide
doxorubicin
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.614458/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.614458/full

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