Functions of huntingtin in germ layer specification and organogenesis.

Huntington's disease (HD) is a neurodegenerative disease caused by abnormal polyglutamine expansion in the huntingtin protein (Htt). Although both Htt and the HD pathogenic mutation (mHtt) are implicated in early developmental events, their individual involvement has not been adequately explore...

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Bibliographic Details
Main Authors: Giang D Nguyen, Aldrin E Molero, Solen Gokhan, Mark F Mehler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3742581?pdf=render