Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100
Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work was to develop modified in sit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2014-03-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0002/acph-2014-0002.xml?format=INT |