Structural Features of Amyloid Fibrils Formed from the Full-Length and Truncated Forms of Beta-2-Microglobulin Probed by Fluorescent Dye Thioflavin T

Structural Features of Amyloid Fibrils Formed from the Full-Length and Truncated Forms of Beta-2-Microglobulin Probed by Fluorescent Dye Thioflavin T

The persistence of high concentrations of beta-2-microglobulin (β2M) in the blood of patients with acute renal failure leads to the development of the dialysis-related amyloidosis. This disease manifests in the deposition of amyloid fibrils formed from the various forms of β2M in t...

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Bibliographic Details
Main Authors: Anna I. Sulatskaya, Natalia P. Rodina, Dmitry S. Polyakov, Maksim I. Sulatsky, Tatyana O. Artamonova, Mikhail A. Khodorkovskii, Mikhail M. Shavlovsky, Irina M. Kuznetsova, Konstantin K. Turoverov
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
beta-2-microglobulin (β2M)
β2M truncated forms
dialysis-related amyloidosis (DRA)
amyloid fibrils
thioflavin T (ThT)
equilibrium microdialysis
binding parameters
Online Access:http://www.mdpi.com/1422-0067/19/9/2762

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http://www.mdpi.com/1422-0067/19/9/2762

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