The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis

The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis

Abstract Background Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)α is known to play a major role in regulation of T cells in SLE, coliti...

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Bibliographic Details
Main Authors: Kim Ohl, Helge Nickel, Halima Moncrieffe, Patricia Klemm, Anja Scheufen, Dirk Föll, Viktor Wixler, Angela Schippers, Norbert Wagner, Lucy R. Wedderburn, Klaus Tenbrock
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Pediatric Rheumatology Online Journal
Subjects:
CREM
JIA
Effector T cells
Online Access:http://link.springer.com/article/10.1186/s12969-018-0253-x

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http://link.springer.com/article/10.1186/s12969-018-0253-x

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