Sequence evolution of the intrinsically disordered and globular domains of a model viral oncoprotein.

In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and evolutionary studies that take into account intrinsic disorder and the conformational diversity of globular domains. The intrinsically disordered (E7N) and globular (E7C) domains of E7 show similar d...

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Bibliographic Details
Main Authors: Lucía B Chemes, Juliana Glavina, Leonardo G Alonso, Cristina Marino-Buslje, Gonzalo de Prat-Gay, Ignacio E Sánchez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3485249?pdf=render